ea0037gp.02.03 | Adrenal (1) | ECE2015
Weigand Isabel
, Ronchi Cristina
, Calebiro Davide
, Rank Petra
, Steinhauer Sonja
, Beuschlein Felix
, Allolio Bruno
, Fassnacht Martin
, Sbiera Silviu
Recently, mutations in the PRKACA (catalytic subunit α of the PKA) gene have been identified as causative in 35% of adrenocortical adenomas (ACA) with overt Cushings syndrome (Beuschlein et al. 2014). These mutations lead to constitutive activation of PKA signaling and subsequently to an excessive production of cortisol. Protein kinase A is a heterotetramer consisting of two catalytic and two regulatory subunits with several isoforms (Cα, β, γ...